Mariamawit Ashenafi
phone: +41 (0)44 63 48275
fax: +41 (0)44 63 48204 Research InterestsKeywords Education List of Publications | |
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The nucleus is more than a genome-packaging organelle. It is ruled by key organizing principles that influence nuclear functions. Some of these functions are conserved between animals and plants suggesting ancestral principles, and some are less understood in plants. For instance, 3D spatial positioning of gene loci relative to the nuclear periphery and to chromosome territories contributes to transcriptional regulation in yeast and metazoans. However, this hasn?t been confirmed in plants. My research aims at describing the organization of the transcriptional compartment in Arabidopsis thaliana in a generic model (leaf) and a specific model, particularly in relation to imprinting (embryo). This study shall reveal evolutionary conservation/divergence of nuclear organizing principles across kingdoms.
Arabidopsis, gene expression, spatial positioning, imprinting, image analysis algorithms
2014 | PhD student (SystemsX.ch program) in Dr. C?lia Baroux's group Institute of Plant Biology, University of Zurich, Switzerland PhD Co-supervisors: Prof. Ueli Grossniklaus (Institute of Plant Biology), Prof. Reinhard F?hrer (Institute of Mathematics), Dr Peter Majer (Bitplane AG) |
2012 - 2013 | MSc in Bioinformatics and Data analysis University Montpellier II, France Master thesis under the supervision of Dr Nicolas Condom: "Irrigation management software development for treated wastewater". |
2010 - 2012 | MSc in Tropical Plant Biotechnology University Montpellier II, France Master thesis: Under the supervision of Dr Christian Cilas: "Coffee tree modeling for indirect high yield selection" Under the supervision of Dr Michel Zivy: "Identification of proteins responsible ovule abortion draught condition" |
2007 - 2010 | Undergraduate Studies (Bachelor) in Agronomy and Food Science University of Haute Alsace, France |
Ashenafi M, Baroux C. (2018) Automated 3D gene position analysis using a customized Imaris plugin: XTFISHInsideNucleus. Methods Mol Biol. 1675:591-613.
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