TREP, the TRansposable Elements Platform

Superfamily ERV                   RLE

Full classification: Retrotransposon, LTR, ERV

ERV elements are Class 1 transposons.

They are extremely well characterized, widespread in vertebrata. ERV are degenerated retroviruses. The terminal repeats usually end in TG (5' end) and CA (3' end).
Upon insertion, they create a 5 bp Target site duplication (TSD).

Structure of ERV elements

Sequence domains

LTR: Long terminal repeat
Function: Contains promoter and terminator elements (dual function).
Protein motifs:

GAG: GAG protein
Function: Required as envelope of virus-like capsid
Protein motifs: CCHC

AP: Aspartic protease
Function:
Protein motifs:

RT: Reverse transcriptase
Function: Reverse transcription of mRNA to DNA, core motif is relatively variable (FY)(IAMV)DD
Protein motifs: YVDD

INT: Integrase
Function:
Protein motifs: HHCC DDE

RH: RNAse H
Function:
Protein motifs: DEDD

ENV: Envelope protein
Function: Retroviral envelope that allows the element to leave the host cell and infect other cells
Protein motifs:

LTR: Long terminal repeat
Function: Contains promoter and terminator elements (dual function).
Protein motifs:

0 ERV Download all 'RLE' elements in total_TREP database elements from the following taxa are in the total_TREP database:

Taxonomic group	Total elements

---